Neonatal Research Institute

Neonatal Karius Study

This study will evaluate the commercially available Karius Test™ in well-appearing, preterm neonates in the NICU. The Karius Test™ detects cell-free plasma bacterial, fungal and viral DNA in a blood sample using next-generation genomic sequencing. The test is typically used in immunocompromised patients, including preterm neonates, assumed to have an infection but who have negative blood culture tests.

This study will determine whether babies who are not suspected of being infected have a positive Karius test result, so that neonatologists have a better understanding of the “background noise” associated with such a sensitive genomic test. Participants will have a one-time 1 mL sample of blood drawn from a vein at the same time as their other routine NICU lab draws. There are no other study procedures. Parents will be told the test results and will also be able to see results in their baby’s medical record using the Sharp app.

PDA Study - NCT03456336

This study will compare the risks and benefits of giving medication versus watchful waiting of a symptomatic patent ductus arteriosus (sPDA) in premature neonates born less than 29 weeks gestational age. This study is not blinded and parents will be aware of what study arm their baby has been randomized to. Most preterm neonates in this GA range do have a sPDA, but it is not clear if giving a baby the FDA-approved medication to close the sPDA is better in the long term compared to watchful waiting for the sPDA to close on its own over time.

NRN Cycled Phototherapy Study - NCT03927833

Jaundice is a normal occurrence, especially in the extremely premature infant population. Phototherapy is used to treat jaundice and is currently being studied if using cycled phototherapy versus continuous phototherapy, will increase the survival of extremely premature infants and keep bilirubin levels in a range that doctors feel is safe.

CORD CHD Study - NCT06153459

This study compares delayed cord clamping (DCC) times for infants (37+0 – 41+6) with congenital heart defects to determine which clamping timepoint is best for babies with heart disease. These babies will either receive 30 seconds or 120 seconds of DCC. There will be follow up at 3 to 4 months, 9 to 12 months and 22 to 26 months to see if there is a difference in development.

DIVA Study - NCT05446272

Invasive mechanical ventilation contributes to chronic lung disease, which is the leading respiratory cause of childhood respiratory problems. Noninvasive ventilation (NIV) may limit invasive ventilation exposure and can be either synchronized or non-synchronized (NS). The DIVA (Diaphragmatic Initiated Ventilatory Assist) trial aims to determine in infants born 240/7-276/7 weeks' gestation undergoing extubation whether NIV-NAVA compared to non-synchronized nasal intermittent positive pressure ventilation (NS-NIPPV) reduces the incidence of extubation failure.

NANO Study - NCT03997266

Early onset sepsis is an important cause of neonatal morbidity and mortality in the preterm population. Infants perceived to be at increased risk for early onset sepsis are often treated empirically with broad-spectrum antibiotics while awaiting confirmatory blood cultures, despite an overall incidence of early onset sepsis of 2-3% among extremely-low-birthweight (ELBW) infants. The NICU Antibiotics and Outcomes (NANO) trial is a multicenter, double-blinded, randomized controlled trial. A sample of ELBW, <30 weeks gestation, preterm infants will be randomized to receive empiric antibiotics (EA; ampicillin and gentamicin) or placebo during routine evaluation for early onset sepsis for the first 72 hours of life.

DOXIE Study - NCT04413097

Premature babies that receive delayed cord clamping may need some breathing support for their immature lungs. Breathing assistance with supplemental oxygen before clamping the umbilical cord may help open their airways and lungs. This study is looking to determine whether providing breathing assistance and supplemental oxygen of 30% or 100% to extremely premature babies during 90 seconds of delayed cord clamping can improve their transition at birth and oxygenation in the first five minutes of birth and improve outcomes for premature infants born less than 29 weeks.

POLAR Study - NCT04372953

Babies born very early need their breathing supported immediately after birth. A common treatment to support premature babies’ breathing is called positive end-expiratory pressure (PEEP). PEEP treatment uses the pressure from airflow to help open the baby’s lungs and keep them supported while breathing. Standard clinical practice is to give infants PEEP beginning at 5 cm H20 and up to 8 cm H2O, based on clinical judgment. It is not known what levels of pressure are best to support babies’ breathing. This research study is being conducted to compare two different ways of giving PEEP to very premature babies immediately after birth, Static PEEP is an approach where babies start and are kept at lower PEEP levels of 5-6 cm H2O, and Dynamic PEEP is an approach where babies start at a higher PEEP level of 8-12 cm H2O and are incrementally increased or decreased depending on their clinical response in the first 20 minutes of life.

• 3-D imaging of babies

• Aerosolized Infasurf

• Antibiotic safety in infants with complicated intra-abdominal infections

• Changes in cardiac output during delayed cord clamping

• Closed system for colostrum collection

• Comparative and reference range study of the UBCheck unbound bilirubin assay for neonatal jaundice

• Dalbavancin pharmacokinetics in preterm and term neonates

• Early caffeine versus routine administration of caffeine on the need for ventilation and cardiac support in preterm babies

• Effectiveness of Infinity Acute Care System

• Effects of prolonged intubation attempts on oxygen saturation and heart rate in preterm infants in the delivery room

• FORE-SIGHT Elite Absolute Tissue Oximeter to measure cerebral and somatic tissue oxygen saturation measurements at different body locations on babies

• Immediate cord clamping versus enhanced placental transfusion on early respiratory support and patent ductus arteriosus outcomes

• Lucinactant for inhalation in preterm babies (26 to 32 weeks gestational age) with respiratory distress syndrome

• Lucinactant for inhalation in preterm babies (26 to 28 weeks gestational age)

• Lucinactant for inhalation in preterm babies (29 to 34 weeks gestational age): dose escalation and study extension

• Milking or delayed cord clamping

• Milking or delayed cord clamping in premature infants

• Multicenter, randomized trial of preterm infants receiving caffeine and less invasive surfactant administration compared to caffeine and early continuous positive airway pressure (CaLI trial)

• Neonatal resuscitation with intact cord

• Neuromonitoring of preterm newborn brain during birth resuscitation

• PFAS in human breastmilk

• Physiological changes with high-flow nasal cannula compared to nasal CPAP in extremely low birth weight infants

• Prediction of newborn brain injury risk

• Premature infants resuscitated with oxygen or air

• Safety of manganese restriction in neonatal parenteral nutrition

• Seizure detection in babies

• Short-delayed cord clamping compared to extended-delayed cord clamping in term infants needing resuscitation

• Sustained inflation in the delivery room

• Tedizolid pharmacokinetics in pediatric participants with Gram-positive infections

• Treatment of ductus arteriosus

• Treatment of neonatal seizures

• Umbilical cord milking in non-vigorous infants

• Director: Dr. Anup Katheria, FAAP

• Follow-up director and NRN Co-PI: Dr. Rebecca Dorner

• Research physician: Dr. Jenny Koo

• Director of CQI: Dr. Katherine Coughlin

• Manager: Alona Diem

• Research coordinators:

  • Gabi Aliyev, DNP, MSN Ed, RNC-MNN

  • Kathy Arnell, RNC

  • Felix Ines, RCP-RRT

  • April Peirson, BSN, RNC-NIC, C-NNIC, IBCLC

  • Catherine Salcido, BS

• Research associates:

  • Malia Devilbiss

  • Irma Estrada

  • Kaitlyn Fitzgerald, BS

  • Lukas Linares

  • Alexis Rosete, BS

• Clinical data management specialist: Wade Rich, BSHS, RRT, CCRC

• Data manager: Ana Morales, BA, MPH

• Research pharmacist: Jason Sauberan, PharmD

• Research data programmer: Shashank Sanjay

• Regulatory coordinator: Marcie Portillo

• Research statistician: Debra Poeltler, PhD, MPH, RN, CCRC

Learn about our recent research developments at the Neonatal Research Institute (NRI):

• The Thrasher Research Fund approved a grant in support of the NRI's NIH-funded PREMOD2 study. The $531,788 grant will be used over three years to support the follow-up efforts of the NRI and its domestic and international partner sites. These efforts will serve babies enrolled in PREMOD2 and ensure their social and cognitive development is on track and they are prepared for success in kindergarten and beyond.

• Sharp Mary Birch received a $5 million donation from the Alexander and Eva Nemeth Foundation to help fund two programs that give at-risk infants a healthier start in life

• The NRI received a $3.1 million research project grant from the National Institutes of Health (NIH), making this our fourth grant from this prestigious body

• In the spring of 2017 the Eunice Kennedy Shriver National Institute of Child Health and Human Development, an institute of the NIH, awarded Sharp Mary Birch a $2.9 million R01 grant. This grant would carry out a multicenter, multinational trial of 1,500 babies to determine if umbilical cord milking is as good as or better than delayed umbilical cord clamping in premature infants.

• The Gerber Foundation awarded the NRI $200,000 to conduct the first study to characterize normal brain function of premature infants during the first 72 hours of life. This is an observational study to evaluate brain perfusion and function using Near Infrared Spectroscopy (NIRS), a monitor that allows us to look at oxygen in the tissue of the brain, and limited EEG monitoring.

• The Thrasher Fund awarded the NRI $175,000 to assess neurodevelopmental follow up of infants in the PREMOD trial at two years of age.

• The Hartwell Foundation provided funding to conduct a trial in term infants to determine if early placement of EEG electrodes and brain oxygen monitoring will allow for early detection of serious poor outcomes. We are constantly searching for ways in which to decrease long-term problems in premature infants, and this study will increase our understanding of newborns' brain function after birth.

• The NIH awarded the NRI a grant of $354,750 to study whether delayed cord clamping can improve long-term brain function for babies needing resuscitation at birth. The study is made possible in part by revolutionary newborn resuscitation beds at Sharp Mary Birch, which allow for delayed cord clamping during newborn resuscitation.

• The Little Giraffe Foundation and Tarsadia Foundation awarded neonatal research grants for more than $10,000. The funds were in support of a study on the respiratory effects of caffeine administered to preterm babies shortly after birth in order to prevent intubation in the first hours of life.

• The NRI was a recipient of a grant, totaling $41,264, from the Will Rogers Institute 2014 Neonatal Ventilator and Pulmonary Grant Program in support of neonatal pulmonary equipment

The following articles highlight studies done at our Neonatal Research Institute:

2024

Koo, J., N. Torres, and A.C. Katheria, Early Echocardiographic Predictors of Eventual Need for Patent Ductus Arteriosus (PDA) Treatment. Am J Perinatol, 2024.

Katheria, A.C., et al., Application of desirability of outcome ranking to the milking in non-vigorous infants trial. Early Hum Dev, 2024. 189: p. 105928.

2023

Seidler, A.L., et al., Short, medium, and long deferral of umbilical cord clamping compared with umbilical cord milking and immediate clamping at preterm birth: a systematic review and network meta-analysis with individual participant data. Lancet, 2023.

Seidler, A.L., et al., Deferred cord clamping, cord milking, and immediate cord clamping at preterm birth: a systematic review and individual participant data meta-analysis. Lancet, 2023.

Sankar, M.N., et al., Transcutaneous bilirubin levels in extremely preterm infants less than 30 weeks gestation. J Perinatol, 2023. 43(2): p. 220-225.

Orton, M., et al., Thermoregulation-Focused Implementation of Delayed Cord Clamping among <34 Weeks' Gestational Age Neonates. Am J Perinatol, 2023.

Katheria, A.C., et al., Parental perspectives on a trial using waived informed consent at birth. J Perinatol, 2023.

Katheria, A., et al., Umbilical Cord Milking Versus Delayed Cord Clamping in Infants 28 to 32 Weeks: A Randomized Trial. Pediatrics, 2023. 152(6).

Katheria, A., et al., Caffeine and Less Invasive Surfactant Administration for Respiratory Distress Syndrome of the Newborn. NEJM Evid, 2023. 2(12): p. EVIDoa2300183.

Sotiropoulos, J.X., et al., PROspective Meta-analysis Of Trials of Initial Oxygen in preterm Newborns (PROMOTION): Protocol for a systematic review and prospective meta-analysis with individual participant data on initial oxygen concentration for resuscitation of preterm infants. Acta Paediatr, 2023. 112(3): p. 372-382.

Sankar, M.N., et al., Transcutaneous bilirubin levels in extremely preterm infants less than 30 weeks gestation. J Perinatol, 2023. 43(2): p. 220-225.

Salcido, C., et al., Maternal bleeding complications and neonatal outcomes following early versus delayed umbilical cord clamping in cesarean deliveries for very low birthweight infants. J Perinatol, 2023. 43(1): p. 39-43.

Mercer, J., A. Katheria, and C.H. Backes, Contemporary controversies in umbilical cord clamping practices. Semin Perinatol, 2023. 47(5): p. 151782.

Koo, J., H. Kilicdag, and A. Katheria, Umbilical cord milking-benefits and risks. Front Pediatr, 2023. 11: p. 1146057.

Koo, J., Z.H. Aghai, and A. Katheria, Cord management in non-vigorous newborns. Semin Perinatol, 2023. 47(4): p. 151742.

Katheria, A.C., et al., Cardiac and cerebral hemodynamics with umbilical cord milking compared with early cord clamping: A randomized cluster crossover trial. Early Hum Dev, 2023. 177-178: p. 105728.

Katheria, A.C., et al., Umbilical cord milking in nonvigorous infants: a cluster-randomized crossover trial. Am J Obstet Gynecol, 2023. 228(2): p. 217.e1-217.e14.

Katheria, A., et al., A Narrative Review of the Rationale for Conducting Neonatal Emergency Studies with a Waived or Deferred Consent Approach. Neonatology, 2023. 120(3): p. 344-352.

Katheria, A., et al., Hemodynamic changes with umbilical cord milking in non-vigorous newborns: A randomized cluster crossover trial. J Pediatr, 2023.

Fite, E.L., et al., Umbilical cord clamping among infants with a prenatal diagnosis of congenital heart disease. Semin Perinatol, 2023. 47(4): p. 151747.

Elsayed, Y., et al., Point-of-care ultrasound (POCUS) protocol for systematic assessment of the crashing neonate-expert consensus statement of the international crashing neonate working group. Eur J Pediatr, 2023. 182(1): p. 53-66.

Edwards, H., R.A. Dorner, and A.C. Katheria, Optimizing transition: Providing oxygen during intact cord resuscitation. Semin Perinatol, 2023. 47(5): p. 151787.

Dorner, R.A., et al., Symptoms of Cerebrospinal Shunt Malfunction in Young Children: A National Caregiver Survey. Child Neurol Open, 2023. 10: p. 2329048x231153513.

Coughlin, K., P. Jen, and A. Katheria, Characteristics and Outcomes in Preterm Infants with Extubation Failure in the First Week of Life. Am J Perinatol, 2023.

Breindahl, N., et al., Curriculum and assessment tool for less invasive surfactant administration: an international Delphi consensus study. Pediatr Res, 2023.

Backes, C.H., J. Mercer, and A. Katheria, Contemporary controversies in umbilical cord clamping practices. Semin Perinatol, 2023. 47(4): p. 151749.

2022

Rasmussen, M., et al., Use of Pulse Oximetry Pulsatility Index Screening for Critical Congenital Heart Disease. Am J Perinatol, 2022.

Quinn, M.K., et al., Delayed Cord Clamping Uptake and Outcomes for Infants Born Very Preterm in California. Am J Perinatol, 2022.

Morowitz, M.J., et al., The NICU Antibiotics and Outcomes (NANO) trial: a randomized multicenter clinical trial assessing empiric antibiotics and clinical outcomes in newborn preterm infants. Trials, 2022. 23(1): p. 428.

Koo, J., A.C. Katheria, and G. Polglase, A newborn's "life line" - A review of umbilical cord management strategies. Semin Perinatol, 2022: p. 151621.

Koo, J. and A. Katheria, Cardiopulmonary Resuscitation with an Intact Umbilical Cord. Neoreviews, 2022. 23(6): p. e388-e399.

Guyon, P., et al., Institutional Trend in Device Selection for Transcatheter PDA Closure in Premature Infants. Pediatr Cardiol, 2022. 43(8): p. 1716-1722.

2021

Sugar, J., et al., Long-term neurodevelopmental outcomes among preterm infants born to mothers with diabetes mellitus. J Perinatol, 2021.

Singh, Y., et al., The evolution of cardiac point of care ultrasound for the neonatologist. Eur J Pediatr, 2021.

Sauberan, J., M. Mercier, and A. Katheria, Sources of unintentional manganese delivery in neonatal parenteral nutrition. JPEN J Parenter Enteral Nutr, 2021.

Mercer, J.S., D.A. Erickson-Owens, and H. Rabe, Placental transfusion: may the "force" be with the baby. J Perinatol, 2021.

Lum, T.G., et al., Two-year neurodevelopmental outcomes of preterm infants who received red blood cell transfusion. Blood Transfus, 2021.

Law, B.H.Y., et al., Higher versus Lower Oxygen Concentration during Respiratory Support in the Delivery Room in Extremely Preterm Infants: A Pilot Feasibility Study. Children (Basel), 2021. 8(11).

Lakshminrusimha, S., et al., Differential Alveolar and Systemic Oxygenation during Preterm Resuscitation with 100% Oxygen during Delayed Cord Clamping. Am J Perinatol, 2021.

Koo, J.K., R. Steinhorn, and C.K. A, Optimizing respiratory management in preterm infants: a review of adjuvant pharmacotherapies. J Perinatol, 2021.

Katheria, A.C., et al., Association between early cerebral oxygenation and neurodevelopmental impairment or death in premature infants. J Perinatol, 2021: p. 1-6.

Katheria, A.C. and L.M. Stellwagen, The Term Infant. Clin Perinatol, 2021. 48(3): p. xxi-xxii.

Katheria, A.C., et al., A Pilot Randomized Trial of Heart Rate Monitoring Using Conventional Versus a New ECG Algorithm During Neonatal Resuscitation at Birth. J Pediatr, 2021.

Katheria, A.C. and J. Koo, Applying the principle 'First Do No Harm' during the pandemic. Bjog, 2021. 128(5): p. 916.

Katheria, A., et al., A review of different resuscitation platforms during delayed cord clamping. J Perinatol, 2021: p. 1-9.

Ines, F., et al., Multicentre, randomised trial of preterm infants receiving caffeine and less invasive surfactant administration compared with caffeine and early continuous positive airway pressure (CaLI trial): study protocol. BMJ Open, 2021. 11(1): p. e038343.

Hutchon, D., S. Pratesi, and A. Katheria, How to Provide Motherside Neonatal Resuscitation with Intact Placental Circulation? Children (Basel), 2021. 8(4).

Ghirardello, S. and A. Katheria, Letter to the Editor RE: Implementation of Delayed Cord Clamping Into Neonatal Algorithms. Pediatrics, 2021.

Bruckner, M., A.C. Katheria, and G.M. Schmölzer, Delayed cord clamping in healthy term infants: More harm or good? Semin Fetal Neonatal Med, 2021: p. 101221.

Ausbeck, E.B., et al., Neonatal Outcomes at Extreme Prematurity by Gestational Age Versus Birth Weight in a Contemporary Cohort. Am J Perinatol, 2021.

Andersson, O. and J.S. Mercer, Cord Management of the Term Newborn. Clin Perinatol, 2021. 48(3): p. 447-470.

2020

Sharpe, C., et al., Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial. Pediatrics, 2020.

Seidler, A.L., et al., Systematic review and network meta-analysis with individual participant data on cord management at preterm birth (iCOMP): study protocol. BMJ Open, 2020. 10(3): p. e034595.

Sauberan, J.B. and A.C. Katheria, Unintentional Manganese Delivery in Neonatal Parenteral Nutrition. J Pediatr Gastroenterol Nutr, 2020.

Marzec, L., et al., Timing of umbilical cord clamping among infants with congenital heart disease. Prog Pediatr Cardiol, 2020. 59.

Katheria, A.C., et al., Early Cardiac and Cerebral Hemodynamics with Umbilical Cord Milking Compared with Delayed Cord Clamping in Infants Born Preterm. J Pediatr, 2020. 223: p. 51-56.e1.

Katheria, A.C., et al., Perinatal Outcomes of Subjects Enrolled in a Multicenter Trial with a Waiver of Antenatal Consent. Am J Perinatol, 2020.

Heyden, C.M., et al., Early experience with the Micro Plug Set for preterm patent ductus arteriosus closure. Catheter Cardiovasc Interv, 2020.

Harbert, M.J.A., et al., Identifying Ways to Fix Outcome Disparities among Outborns Needing Therapeutic Hypothermia. American journal of perinatology, 2020: p. 10.1055/s-0040-1702990.

Gantz, M.G., et al., Achieved oxygen saturations and retinopathy of prematurity in extreme preterms. Arch Dis Child Fetal Neonatal Ed, 2020. 105(2): p. 138-144.

Finer, N.N. and A. Katheria, Recruitment: the best way to IN-SUR-E surfactant delivery? Lancet Respir Med, 2020.

Cummings, J.J., et al., Aerosolized Calfactant for Newborns With Respiratory Distress: A Randomized Trial. Pediatrics, 2020. 146(5).

Clyman, R.I., et al., Prolonged tracheal intubation and the association between patent ductus arteriosus and bronchopulmonary dysplasia: a secondary analysis of the PDA-TOLERATE trial. J Pediatr, 2020.

Chiruvolu, A., et al., Variations in umbilical cord clamping practices in the United States: a national survey of neonatologists. J Matern Fetal Neonatal Med, 2020: p. 1-7.

Chandrasekharan, P., et al., Neonatal Resuscitation and Postresuscitation Care of Infants Born to Mothers with Suspected or Confirmed SARS-CoV-2 Infection. Am J Perinatol, 2020. 37(8): p. 813-824.

2019

Truong, L., et al., Haemodynamic effects of premedication for neonatal intubation: an observational study. Arch Dis Child Fetal Neonatal Ed, 2019.

Sharpe, C., et al., Assessing the Feasibility of Providing a Real-Time Response to Seizures Detected With Continuous Long-Term Neonatal Electroencephalography Monitoring. J Clin Neurophysiol, 2019. 36(1): p. 9-13.

Sauberan, J.B., High-Dose Vitamins. Breastfeed Med, 2019. 14(5): p. 287-289.

Rich, W.D. and A.C. Katheria, Waived Consent in Perinatal/Neonatal Research-When Is It Appropriate? Front Pediatr, 2019. 7: p. 493.

Mahadevan, U., et al., Inflammatory Bowel Disease in Pregnancy Clinical Care Pathway: A Report From the American Gastroenterological Association IBD Parenthood Project Working Group. Am J Obstet Gynecol, 2019. 220(4): p. 308-323.

Liebowitz, M., et al., Lack of Equipoise in the PDA-TOLERATE Trial: A Comparison of Eligible Infants Enrolled in the Trial and Those Treated Outside the Trial. J Pediatr, 2019. 213: p. 222-226.e2.

Liebowitz, M., et al., Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320). J Perinatol, 2019. 39(5): p. 599-607.

Kirpalani, H., et al., Effect of Sustained Inflations vs Intermittent Positive Pressure Ventilation on Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants: The SAIL Randomized Clinical Trial. Jama, 2019. 321(12): p. 1165-1175.

Katheria, A.C., W.D. Rich, and S. Lakshminrusimha, Circulatory emergencies in the delivery room. Semin Fetal Neonatal Med, 2019: p. 101030.

Katheria, A.C., et al., Placental Transfusion for Asphyxiated Infants. Front Pediatr, 2019. 7: p. 473.

Katheria, A.C., et al., Resuscitation outcomes of infants that do not achieve a 5 min target SpO2 saturation. J Perinatol, 2019.

Katheria, A.C., et al., Stem Cell Composition of Umbilical Cord Blood Following Milking Compared with Delayed Clamping of the Cord Appears Better Suited for Promoting Hematopoiesis. J Pediatr, 2019.

Katheria, A.C., Neonatal Resuscitation with an Intact Cord: Current and Ongoing Trials. Children (Basel), 2019. 6(4).

Katheria, A., et al., Association of Umbilical Cord Milking vs Delayed Umbilical Cord Clamping With Death or Severe Intraventricular Hemorrhage Among Preterm Infants. Jama, 2019. 322(19): p. 1877-1886.

2018

Singh, Y., A.C. Katheria, and F. Vora, Advances in Diagnosis and Management of Hemodynamic Instability in Neonatal Shock. Front Pediatr, 2018. 6: p. 2.

Singh, Y., A. Katheria, and C. Tissot, Functional Echocardiography in the Neonatal Intensive Care Unit. Indian Pediatr, 2018. 55(5): p. 417-424.

Ruangkit, C., et al., Maternal bleeding complications following early versus delayed umbilical cord clamping in multiple pregnancies. BMC Pregnancy Childbirth, 2018. 18(1): p. 131.

Oei, J.L., et al., Outcomes of oxygen saturation targeting during delivery room stabilisation of preterm infants. Arch Dis Child Fetal Neonatal Ed, 2018. 103(5): p. F446-f454.

Katheria, V., et al., Early prediction of a significant patent ductus arteriosus in infants <32 weeks gestational age. J Neonatal Perinatal Med, 2018. 11(3): p. 265-271.

Katheria, A.C., et al., Acceptability of Bedside Resuscitation With Intact Umbilical Cord to Clinicians and Patients' Families in the United States. Front Pediatr, 2018. 6: p. 100.

Katheria, A.C., et al., The Neu-Prem Trial: Neuromonitoring of Brains of Infants Born Preterm During Resuscitation-A Prospective Observational Cohort Study. J Pediatr, 2018. 198: p. 209-213.e3.

Katheria, A.C., Umbilical Cord Milking: A Review. Front Pediatr, 2018. 6: p. 335.

Katheria, A., S. Hosono, and W. El-Naggar, A new wrinkle: Umbilical cord management (how, when, who). Semin Fetal Neonatal Med, 2018.

Harbert, M.J., et al., Impact of a neuro-intensive care service for newborns. J Neonatal Perinatal Med, 2018. 11(2): p. 173-178.

Clyman, R.I., et al., PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age. J Pediatr, 2018.

Brown, M.K., et al., Incidence of Hypocapnia, Hypercapnia, and Acidosis and the Associated Risk of Adverse Events in Preterm Neonates. Respir Care, 2018. 63(8): p. 943-949.

2017

Wang, J., et al., Evaluation of the Safety of Drugs and Biological Products Used During Lactation: Workshop Summary. Clin Pharmacol Ther, 2017. 101(6): p. 736-744.

Sauberan, J.B., et al., Quality and Clinical Outcomes Associated with a Gentamicin Use System Change for Managing Chorioamnionitis. J Med Syst, 2017. 41(12): p. 202.

Rich, W.D. and A.C. Katheria, Waiver of Consent in a Trial Intervention Occurring at Birth-How Do Parents Feel? Front Pediatr, 2017. 5: p. 56.

Oei, J.L., et al., Higher or lower oxygen for delivery room resuscitation of preterm infants below 28 completed weeks gestation: a meta-analysis. Arch Dis Child Fetal Neonatal Ed, 2017. 102(1): p. F24-f30.

Katheria, A.C., et al., Placental transfusion: a review. J Perinatol, 2017. 37(2): p. 105-111.

Katheria, A.C., et al., Providing a Placental Transfusion in Newborns Who Need Resuscitation. Front Pediatr, 2017. 5: p. 1.

Katheria, A.C., et al., Hemodynamic effects of sodium bicarbonate administration. J Perinatol, 2017. 37(5): p. 518-520.

Katheria, A.C., et al., Delayed Cord Clamping in Newborns Born at Term at Risk for Resuscitation: A Feasibility Randomized Clinical Trial. J Pediatr, 2017. 187: p. 313-317.e1.

Katheria, A., et al., Umbilical cord milking at birth for term newborns with acidosis: neonatal outcomes. J Perinatol, 2017.

Katheria, A., et al., A Randomized Clinical Trial of Umbilical Cord Milking vs Delayed Cord Clamping in Preterm Infants: Neurodevelopmental Outcomes at 22-26 Months of Corrected Age. J Pediatr, 2017.

Katheria, A., et al., A pilot randomized controlled trial of EKG for neonatal resuscitation. PLoS One, 2017. 12(11): p. e0187730.

Gephart, S.M., et al., NEC-zero recommendations from scoping review of evidence to prevent and foster timely recognition of necrotizing enterocolitis. Maternal Health Neonatology Perinatology, 2017. 3: p. 23.

2016

Wozniak, M., et al., The 30 second rule: the effects of prolonged intubation attempts on oxygen saturation and heart rate in preterm infants in the delivery room. Minerva Pediatr, 2016.

Sauberan, J.B., et al., Stability and Osmolality of Extemporaneously Prepared Clonidine Oral Liquid for Neonates. Ann Pharmacother, 2016. 50(3): p. 243-4.

Navarrete, C.T., et al., Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth. J Pediatr, 2016. 176: p. 62-68.e4.

Katheria, A., W. Rich, and N. Finer, Optimizing Care of the Preterm Infant Starting in the Delivery Room. Am J Perinatol, 2016. 33(3): p. 297-304.

Katheria, A., et al., Neonatal Resuscitation with an Intact Cord: A Randomized Clinical Trial. J Pediatr, 2016. 178: p. 75-80.e3.

Brown, M.K., et al., Resistance of Colorimetric Carbon Dioxide Detectors Commonly Utilized in Neonates. Respir Care, 2016. 61(8): p. 1003-7.

Anderson, P.O. and J.B. Sauberan, Modeling drug passage into human milk. Clin Pharmacol Ther, 2016. 100(1): p. 42-52.

Akotia, D.H., et al., Relationship Between Near-Infrared Spectroscopy and Transabdominal Ultrasonography: Noninvasive Monitoring of Intestinal Function in Neonates. Med Sci Monit, 2016. 22: p. 61-8.

2015

Katheria, A.C., et al., Measuring cardiac changes using electrical impedance during delayed cord clamping: a feasibility trial. Maternal Health, Neonatology and Perinatology, 2015. 1(1).

Katheria, A.C., et al., Umbilical Cord Milking Versus Delayed Cord Clamping in Preterm Infants. Pediatrics, 2015. 136(1): p. 61-9.

Katheria, A.C., et al., A Pilot Randomized Controlled Trial of Early versus Routine Caffeine in Extremely Premature Infants. Am J Perinatol, 2015. 32(9): p. 879-86.

Hintz, S.R., et al., Neuroimaging and neurodevelopmental outcome in extremely preterm infants. Pediatrics, 2015. 135(1): p. e32-42.

2014

Stevens, T.P., et al., Respiratory outcomes of the surfactant positive pressure and oximetry randomized trial (SUPPORT). J Pediatr, 2014. 165(2): p. 240-249.e4.

Song, R., et al., The use of electrical cardiometry for continuous cardiac output monitoring in preterm neonates: a validation study. Am J Perinatol, 2014. 31(12): p. 1105-10.

Olsen, R.N., J. Shepherd, and A. Katheria, Postnatal systemic blood flow in neonates with abnormal fetal umbilical artery Doppler. ISRN Obstet Gynecol, 2014. 2014: p. 957180.

Le, C.N., et al., Impact of premedication on neonatal intubations by pediatric and neonatal trainees. J Perinatol, 2014. 34(6): p. 458-60.

Katheria, A.C., et al., The effects of umbilical cord milking on hemodynamics and neonatal outcomes in premature neonates. J Pediatr, 2014. 164(5): p. 1045-1050 e1.

Finer, N.N. and A. Katheria, Bedside hemodynamic evaluation for neonates receiving respiratory support. J Pediatr, 2014. 164(4): p. 683-4.

Finer, N.N. and A. Katheria, Slow to change: new cord clamping policies for premature infants. J Neonatal Perinatal Med, 2014. 7(2): p. 85-7.

Blank, D., et al., Pedi-cap color change precedes a significant increase in heart rate during neonatal resuscitation. Resuscitation, 2014. 85(11): p. 1568-72.